Inflammation Panel

$227 available on subscription from $219 every 3 months

Check the levels of inflammation in your body.

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An increasing body of evidence has shown that chronic inflammation can cause or advance many common chronic diseases, with higher levels of cellular inflammation indicating a greater risk of the development of and/or accelerated progression towards chronic disease.  These 4 tests combined can help identify your current level of cellular inflammation and how it could be improved.  Each of these are measured using blood spot test cards.

  • Vitamin D – higher levels linked to less inflammation
  • Omega-3 Index with AA:EPA and Omega-6:Omega-3 Ratios – directly inhibits the inflammatory process
  • CRP (C-Reactive Protein) – marker of inflammation in the body
  • HbA1c (Glycated hemoglobin) – measures the health of recent blood sugar levels

More Information:
Vitamin D
The most accurate measurement of vitamin D status can be determined by measuring the amount of 25(OH)D in the blood. Anywhere between 40-75% of the world’s population is vitamin D deficient. A Scientists’ Call to Action has been issued by 48 international vitamin D researchers to alert the public to the importance to have vitamin D serum levels between 40 and 60 nanograms/milliliter (100-150 nanomoles/liter) to prevent disease.

Omega-3 Index
The Omega-3 Index is a measure of the amount of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in red blood cell membranes. The result is expressed as a percent of total RBC fatty acids, and is a long-term and stable marker of omega-3 status throughout the blood and tissues.

AA:EPA Ratio
The AA:EPA Ratio test measures the ratio of the amount of the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid eicosapentaenoic acid (EPA) in the cells. This test is a measurement of the amount of bad fats to good fats in the cells, and it can be an indication of the amount of cellular inflammation in the body, since AA is pro-inflammatory and EPA is anti-inflammatory.

Omega-6:Omega-3 Ratio
The Omega-6:Omega-3 Ratio test is another way to measure the amount of bad fats to healthy fats in the body. Both tests can provide guidance to specific dietary changes that could support improvements in chronic inflammation and disease.

Hemoglobin A1c
HbA1c is a measure of how healthy average blood sugar levels have been in the recent few months, and is a better representation of blood sugar health than a single glucose measurement, since glucose levels vary throughout the day. HbA1c is the compound formed in the blood when a hemoglobin molecule in a red blood cell binds with a glucose molecule in the blood; the resulting molecule is also known as glycated hemoglobin. It can be a good indicator of glucose intolerance even in the absence of abnormal fasting glucose levels.

High Sensitivity C-Reactive Protein (hs-CRP)
C-reactive protein (CRP) is a marker of the amount of inflammation in the body. High levels are seen in acute inflammation and have been correlated with high cardiovascular disease risk, while smaller elevations are indicative of chronic inflammation and chronic diseases, such as metabolic syndrome and diabetes.

Enrollment with the purchase of a Vitamin D*action blood spot test kit includes:

  • 2-3 lancets
  • Blood spot card(s) for the tests ordered
  • 1 envelope for returning your blood spot card
  • 1 gauze pad, 1 band aid, and 1 alcohol swab
  • Vitamin D*action literature

When you order your kit, you will also be participating as a citizen scientist in the world’s largest vitamin D project to solve the deficiency, D*action. You may choose to enroll for a 1-time test with your health information, or you may even participate in the 5-year project, where you provide your health information along with a vitamin D test every 6 months for the 5-year period. Your participation over the next five years will help build a body of science that will allow for tracking health care outcomes associated with vitamin D levels, and other important nutrients.

Questionnaire & Citizen Science

Becoming a participant of GrassrootsHealth means that you are joining thousands of people in collaborating with us on nutrient research. Citizen science welcomes everyone’s participation in the discovery and sharing of scientific knowledge. As a citizen scientist, you can help everyone gain a better understanding of the role of nutrients in health and disease, and use the results to help inform public health officials to create change. Additionally, you can use your results to make informed decisions about nutrients that affect your health.Here’s to the power of citizen science!

GrassrootsHealth could provide testing without asking you to fill out a questionnaire, but without that data we would have no way of measuring an effect. It would be a public service, especially back in 2009 when we started and it was hard to get a doctor to order a vitamin D test. But we founded GrassrootsHealth for more than testing. We founded GrassrootsHealth based on science, by first gathering together over 40 vitamin D researchers to form a panel of experts, then having those researchers come to a consensus on what the optimal vitamin D blood levels should be for general good health. The consensus they reached was for vitamin D levels to be in the range of 40-60 ng/ml (100-150 nmol/L). By asking about health, nutrient supplementation, and other exposures we can connect each participant’s blood levels with their lifestyle and health status and help guide scientific answers to personal questions. In short, your data matters!

Learn more about the importance of the questionnaire.

Your individual health data will be kept confidential except for where required by law. The accumulated data will be stored in a secured, encrypted database operating behind a firewall, and password protected. The only person that will have access to the identified data will be our primary data biostatistician. This will be for purposes of accessing hospital records as indicated and released by participants, or for clarification of entries in the health questionnaire. The de-identified health information is shared so the research can be conducted, properly monitored and published. The Principal Investigator and other researchers will access the data in a de-identified form. For all analyses only an arbitrary number will identify the participant.
Vitamin D3 (cholecalciferol) is a prohormone produced endogenously from the action of ultraviolet light on its precursor, 7-dehydrocholesterol, in the skin, and is also commonly found in over-the-counter vitamin D supplements. Vitamin D2 (ergocalciferol) does not occur naturally, but is manufactured commercially by exposing ergosterol to ultraviolet light, and is the predominant form obtained by prescription in the US. Both are hydroxylated in the liver to form their 25-hydroxy metabolites (25(OH)D2 and 25(OH)D3), the major circulating form of vitamin D in the blood and the commonly accepted measure of vitamin D status. The blood spot assay is performed using liquid chromatography/ tandem mass spectrometry (LC-MS/MS), the same method used by the CDC Nutrition Laboratory to obtain accurate 25(OH) D values. Method accuracy is ensured by standardization with the NIST vitamin D standard reference materials. Circulating 25(OH)D3 levels reflect endogenous production as well as vitamin supplementation, whereas 25(OH)D2 levels reflect the results of Vitamin D2 supplementation. Vitamin D2 is believed to be less bioactive than vitamin D3. Vitamin D deficiency is linked with many chronic diseases, including autoimmune diseases, diabetes, cardiovascular disease, and cancer. Optimal levels of 25(OH)D3 are 32—100 ng/mL.